一對(duì)十二歲的雙胞胎男孩Zack(DylanSprouse)和Cody(ColeSprouse)還有他們的媽媽是這所波斯頓高檔Tipton酒店的長(zhǎng)期住客。在這里，他們認(rèn)識(shí)了新朋友London(BrendaSong)和Maddie(AshleyTisdale)。Zack和Cody接二連三的惡作劇把Tipton旅館變成了他們的游樂(lè)場(chǎng)。在搞笑、搗蛋、引發(fā)混亂的同時(shí)，也帶著London和Maddie瘋了一回。Outrageousshenanigansensuewhen12-year-oldtwinboysZack(DylanSprouse)andCody(ColeSprouse)turntheupscaleBostonhotelwheretheylive(TheTipton)intotheirownpersonalplayground.LivinginasuitewiththeirmomCarey,theboysoftentaketheirnewfriendsLondonandMaddiealongfortheride,astheycausemischief,mayhem,andvariouscatastrophesintheirelegantnewdigs.